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KMID : 0613820210310060574
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Journal of Life Science
2021 Volume.31 No. 6 p.574 ~ p.580
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Comparison of the Pathogenicity of Infectious Hematopoietic Necrosis Virus Genotypes Isolated from Rainbow Trout in Gangwon Province
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Lee Chang-Ju
Kim Kwang-Il
Han Yu-Seon
Jegal Myeong-Eun
Kim Yung-Jin
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Abstract
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This study investigated the pathogenicity of different genotypes of infectious hematopoietic necrosis virus (IHNV) strains isolated from infected rainbow trout in Gangwon Province. RtPc0314c and RtPc0314g strains belonging to the JRt-Shizuoka lineage and RtPc0816g strain belonging to the JRt- Nagano lineage showed 100% cumulative mortality when inoculated at a high titer. In addition, more rapid necrosis was observed in rainbow trout infected with RtPc0314c and RtPc0314g mutations. When inoculated at a low titer, 100% mortality was not observed until the end of the experiment, but the mortality was higher in rainbow trout infected with a mutant strain belonging to the JRt-Shizuoka linage than a mutant strain belonging to the JRt-Nagano lineage. A histopathological analysis showed a clear signature of infection in kidney and spleen tissues upon infection with RtPc0314c and RtPc0314g but no signature of infection associated with the Rt03186 strain. Based on the results in this study, it seems that strains belonging to the JRt-Shizuoka lineage in Gangwon Province IHNV are more pathogenic.
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KEYWORD
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Cumulative mortality, Histologic analysis, IHNV, Pathogenicity, Serotype
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